Ben Callahan of Sparkbox tackles hands-on responsive and adaptive web design. You can view Ben’s presentation over at SpeakerDeck.
My favorite portion of his deck comes at slide 34. Here he lists a short Pros/Cons list when deciding whether to go for large resolutions first or small resolutions first (a.k.a. mobile first). Good things to think about. Sparkbox prefers mobile first and Ben goes on to explain why.